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Some sedatives can cause physiological and psychological dependence when taken regularly over a period of time, even at therapeutic doses.
Dependent users may get withdrawal symptoms ranging from restlessness and insomnia to convulsions and death.
Sedatives and alcohol are sometimes combined recreationally or carelessly.
Since alcohol is a strong depressant that slows brain function and depresses respiration, the two substances compound each other's actions and this combination can prove fatal.
The long-term use of benzodiazepines may have a similar effect on the brain as alcohol, and are also implicated in depression, anxiety, posttraumatic stress disorder (PTSD), mania, psychosis, sleep disorders, sexual dysfunction, delirium, and neurocognitive disorders (including benzodiazepine-induced persisting dementia which persists even after the medications are stopped).